Dozens of people have been injured as more than 130 vehicles were involved in a series of crashes in thick fog on the A249 Sheppey crossing in Kent.
Eight of those hurt in the collisions, which took place at about 07:15 BST, have serious injuries.
Early reports said 200 people had been hurt, but police later revised the figure.
Firefighters said they had freed five people from their vehicles on the southbound carriageway.
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End Quote Martin Stammers EyewitnessA woman came up to us sobbing saying, 'thank you, thank you, you saved my life"
One witness said visibility had been very poor at the time of the crash but drivers were approaching the crossing with no lights.
Others at the scene described a mass of tangled cars, lorries, and a car transporter. Some reports said the crash went on for 10 minutes as cars continuously collided with each other.
Driver Martin Stammers said the scene was "horrendous" and described seeing cars under lorries and people lying on the floor.
He said visibility was about 10 to 20 yards when he approached the bridge and saw five cars smashed into each other with one across the outside lane.
He said he managed to squeeze through a gap between that car and the central reservation, he said.
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Aerial footage shows the aftermath of the collisions, which happened in thick fog
"For 10 minutes afterwards, all we could hear was screeching, cars thudding into each other, lorries crashing," he added.
He said he and his son ran to warn other drivers and warn cars to slow down.
"Later, a woman came up to us sobbing saying, 'thank you, thank you, you saved my life'," he said.
'Smashed cars everywhere'Jaime Emmett, a 19-year-old student who was driving through the fog, said she managed to stop in time but a van collided with her car, and she then hit a car in front.
She said the fog was so thick she could only see a few cars ahead but added: "All I could hear was the cars smashing in front of each other and I could not know how far ahead the accident was."
Later she said she could see "smashed cars everywhere", a lorry that had crashed into the central reservation, and ambulance crews helping injured people with one team carrying a man in a stretcher.
Continue reading the main storyCh Insp Andy Reeves said the crash was over a "protracted area" with undamaged vehicles between others which had collided.
The injured people were taken to six different hospitals.
'Hazardous fog'When asked if the fog had caused the crash, Mr Reeves said it was "too early" to give a cause but added the "weather will be a factor".
At the scene
Simon Jones BBC South East reporter
It was almost a domino effect you had happening on this crossing.
In total about 130 vehicles have been involved with many people injured.
Emergency services are still dealing with some of the more seriously injured casualties as well as the people who walked away from their vehicles.
I've seen someone being wheeled to an ambulance who looked in a pretty bad condition, he was on a stretcher with a support around his head.
Police have said this crossing is going to be shut, potentially, for the entire day. The 130 vehicles involved in the incident will all have to be moved but before that officers have to begin an investigation into the causes of the crash.
"It was... very hazardous. It was described to me as a very thick fog and it was certainly low visibility at the time."
He said he expected the crossing to remain closed in both directions for the whole of the working day, including the evening rush hour.
The front of the crash happened where traffic was coming off the bridge towards Sittingbourne, and it had then "concertinaed" over the bridge behind it with incidents stretching back to Queenborough, he said.
Mr Reeves said there could also be a small number of incidents on the northbound carriageway.
Police said if people had to make essential journeys to the island they could use the old Kingsferry Bridge, but should expect long delays.
Sittingbourne and Sheppey MP Gordon Henderson said he had previously had concerns about lighting on the bridge and said he would be asking questions of the authorities about the accident.
He added: "Today my concerns must rest solely with the people that have been injured on the bridge."
The £100m four-lane crossing, which connects the Isle of Sheppey with mainland Kent, opened in 2006 and is 0.75 miles (1.25km) long and rises to 115ft (35m) at its highest point.
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